Puerarin

Puerarin, a natural isoflavone, is commonly used as a Chinese herbal medicine for the treatment of various cardiovascular and neurological disorders. It has been found to be neuroprotective via TrK‐PI3K/Akt pathway, which is associated with anti‐inflammatory and antioxidant effects. Myelin damage in diseases such as multiple sclerosis (MS) and ischemia induces activation of endogenous oligodendrocyte progenitor cells (OPC) and subsequent remyelination by newly formed oligodendrocytes. It has been shown that human‐induced pluripotent stem cells (hiPSC)‐derived OPCs promote remyelination when transplanted to the brains of disease models.

Remyelination is a key aspect of neural repair and functional recovery.

Oligodendrocytes (OL) are the myelinating cells of the central nervous

system (CNS). Myelination enables rapid transmission of action potentials and provides trophic support to axons. Accumulated evidence shows that many neurological conditions are associated with myelin damage, such as MS, ischemia, and Alzheimer's disease (AD). Failure of remyelination in MS eventually leads to progressive neuronal loss and irreversible functional deficits. (Xu et al., 2025)

Puerarin

  • Promotes oligodendrocyte generation: Puerarin increases the number of myelin-forming cells by promoting the proliferation of oligodendrocyte precursor cells (OPCs)
  • Enhances mitochondrial function: It increases the activity of mitochondria in OPCs, which is essential for their development into oligodendrocytes
  • Supports myelin repair: In experiments using rat brain slices and mouse spinal cords, puerarin was shown to promote both initial myelination and the repair of existing myelin
  • Increases oligodendrocyte repopulation: In a mouse model of demyelinationpuerarin increased the number of oligodendrocytes that repopulated the damaged area

Xu, H., Zhang, H., Pop, N., Hall, J., Shazlee, I., Wagner-Tsukamoto, M., Chen, Z., Gu, Y., Zhao, C., & Ma, D. (2025). The isoflavone puerarin promotes generation of human iPSC-derived pre-oligodendrocytes and enhances endogenous remyelination in rodent models. J Neurochem, 169(1), e16245. https://doi.org/10.1111/jnc.16245

Suitable for vegetarians. Contains no yeast, dairy, egg, gluten, soy or wheat, sugar, starch, salt, preservatives, or artificial color, flavor or fragrance. Not to be used in patients under 18 years old.