This section is provided for qualified healthcare practitioners as professional education. It summarises selected ingredient-level and pathway-level research. It does not represent additional ARTG indications for Zonulin1.
Zonulin and gastrointestinal barrier research
Zonulin and tight junction regulation have become important areas of gastrointestinal barrier research. Published literature has explored the role of zonulin in intestinal permeability, epithelial barrier function and immune-related pathways.
This information is provided as scientific background for practitioners and should not be interpreted as a product indication.
Tight junction and inflammatory pathway research
Tight junctions are key structures involved in gastrointestinal barrier function. Published research has explored how epithelial permeability and tight junction integrity may be influenced by inflammatory, immune and oxidative stress pathways.
Zonulin1 contains ingredients associated with traditional herbal constituents including saikosaponins, paeoniflorin, naringin and glycyrrhizic acid, which have been discussed in scientific literature in relation to inflammatory pathways, oxidative stress, epithelial permeability and gastrointestinal barrier research.
Ingredient research highlights
Bupleurum falcatum
Contains saikosaponins, which have been discussed in literature relating to inflammatory signalling pathways, including NF-κB and MAPK-related mechanisms.
Paeonia lactiflora
Contains paeoniflorin, a constituent discussed in literature relating to immune and inflammatory pathway research.
Citrus aurantium
Contains flavonoid constituents such as naringin and naringenin, which have been explored in oxidative stress and inflammatory pathway research.
Glycyrrhiza uralensis
Contains glycyrrhizic acid and related flavonoids, which have been discussed in literature relating to antioxidant and inflammatory pathways.
Lactobacillus acidophilus
Has been explored in gastrointestinal barrier and tight junction research.
The above information is provided to support professional understanding of selected ingredients and biological pathways. It should not be used to promote Zonulin1 for any disease indication not included in the ARTG entry.
References available to registered practitioners on request.