DownTime (Fulnight)
Down)Time combines well-researched botanicals to sedate and promote solid, deep relaxation. Added to these powerful but gentle herbs is Camellia sinensis (containing L-Theanine), which reduces the 'adrenal' effects, associated with stress.
| Ingredients |
|---|
| Eclipta prostrata |
| Valeriana officinalis |
| Ziziphus jujuba |
| Passiflora incarnata |
| Polygala sibirica |
| Camellia sinensis (L-Theanine) |
| Matricaria chamomilla |
| Wolfiporia cocos |
| Albizziae julibrissin |
| Anemone altaica |
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
Fulnight
60 x 500 mg Capsules
Actions
Increases REM sleep
Brings sleep on faster
Decreases the degradation of GABA to sedate CNS and increases feelings of peacefulness
Has hypnotic effect
Synergistic effect with phenylalanine on central nervous system function
Indications
Insomnia, Acute and Chronic
Difficulty falling asleep
Frequent night-time urination (Nocturia)
Waking too early in the morning
Unrefreshing sleep
Suggested Use:
Adult dosage: 2 capsules, 3 hours before sleep
Caution:
Orally, Valerian can cause headache, excitability and uneasiness. Occasionally, Valerian may cause gastric discomfort, dry mouth, vivid dreams, and morning drowsiness. Orally, Passionflower can cause dizziness, confusion, and ataxia in some patients.
Warning:
Do not use with pregnancy, lactation, hypotension. Not suitable for children under 12 years of age.
Valerian
Valerian is used as a sedative-hypnotic for insomnia and as an anxiolytic (anxiety reducer) for restlessness and sleeping disorders associated with anxiety. It has also been used for mood disorders such as depression, infantile convulsions, mild tremors, epilepsy, and attention deficit-hyperactivity disorder (ADHD).
Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
Ziegler G ,Ploch M , Miettinen-Baumann A , Collet W. European Journal of Medical Research [01 Nov 2002, 7(11):480-486]
Patients aged 18 to 73 years and diagnosed with non-organic insomnia according to ICD-10 (F 51.0) were treated in a multicentre, double-blind, randomised parallel group comparison with either 600 mg/die valerian extract LI 156 (Sedonium) or 10 mg/die oxazepam taken for 6 weeks. A total of 202 outpatients with a mean duration of insomnia of 3.5 months at baseline were included at 24 study centres (general practices) in Germany. - Sleep quality (SQ) after 6 weeks measured by the Sleep Questionnaire B (SF-B; CIPS 1996) showed that 600 mg/die valerian extract LI 156 was at least as efficacious as a treatment with 10 mg/die oxazepam. Both treatments markedly increased sleep quality compared with baseline (p <0.01). The other SF-B subscales, i.e. feeling of refreshment after sleep (GES), psychic stability in the evening (PSYA), psychic exhaustion in the evening (PSYE), psychosomatic symptoms in the sleep phase (PSS), dream recall (TRME), and duration of sleep confirmed similar effects of both treatments. Clinical Global Impressions scale (CGI) and Global Assessment of Efficacy by investigator and patient, again, showed similar effects of both treatments. Adverse events occurred in 29 patients (28.4%) receiving valerian extract LI 156 and 36 patients (36.0%) under oxazepam, and were all rated mild to moderate. No serious adverse drug reactions were reported in either group. Most patients assessed their respective treatment as very good (82.8% in the valerian group, 73.4% in the oxazepam group). During the 6 week treatment phase Valerian extract LI 156 (Sedonium) 600 mg/die showed a comparable efficacy to 10 mg/die oxazepam in the therapy of non-organic insomnia.
Theanine
Theanine is the major amino acid found in green tea. Green tea contains 1% to 3% theanine. There is interest in using theanine to prevent and treat dementia. Theanine demonstrates a protective effect by decreasing ischemic neuronal death in the forebrains of animal models. The antagonistic effects of theanine on glutamate and N-methyl-D-aspartate (NMDA) receptors might provide neuroprotection.
There is also interest in using theanine for hypertension. Theanine affects catecholamine’s that can cause vasoconstriction and lead to elevations in blood pressure. In animal models, theanine decreases norepinephrine levels, decreases systolic and diastolic blood pressure, and suppresses the stimulatory effects of caffeine (Voung et al., 2011).
Chamomile Extract
Chamomile Extract is standardized to 1.2% apigenin. Chamomile Extract has a calming effect on smooth muscle tissue and nerves, and may be useful as a remedy for nervous stomach, insomnia, skin irritations, toothaches, indigestion, anxiety, fever, headache, pain, gas, and colic. Chamomile Extract gently reduces anxiety and can help induce sleep. It is excellent for relieving gas, colic and digestive upset due to stress and anxiety.
Chamomile: A herbal medicine of the past with bright future. Molecular medicine reports.
Srivastava JK, Shankar E, Gupta S. Chamomile: 2010;3(6):895-901. doi:10.3892/mmr.2010.377.
Chamomile is one of the most ancient medicinal herbs known to mankind. It is a member of Asteraceae/Compositae family and represented by two common varieties viz. German Chamomile (Chamomilla recutita) and Roman Chamomile (Chamaemelum nobile). The dried flowers of chamomile contain many terpenoids and flavonoids contributing to its medicinal properties. Chamomile preparations are commonly used for many human ailments such as hay fever, inflammation, muscle spasms, menstrual disorders, insomnia, ulcers, wounds, gastrointestinal disorders, rheumatic pain, and haemorrhoids. Essential oils of chamomile are used extensively in cosmetics and aromatherapy. Many different preparations of chamomile have been developed, the most popular of which is in the form of herbal tea consumed more than one million cups per day. In this review we describe the use of chamomile in traditional medicine with regard to evaluating its curative and preventive properties, highlight recent findings for its development as a therapeutic agent promoting human health.
Jujuboside
Jujuboside is a hypnotic and sedative. The seeds and leaves of Zizyphus spinosa exert an inhibiting effect on central nervous system function, while the fruits have a synergism with pentobarbital sodium and thiopental sodium on prolongation of sleep and sedation, and also decrease coordinated action. Jujuboside A exerts no inhibiting effect, but has a synergistic effect with phenylalanine on central nervous system function. Treats palpitations and insomnia as well as tranquilizing the mind.
Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety.
Peng WH, Hsieh MT, Lee YS, Lin YC, Liao J. J Ethnopharmacol. 2000 Oct;72(3):435-41.
The aim of the present study was to investigate the ethanolic extract of Semen Ziziphi jujuba (SZJE) induced anxiolytic effect. The SZJE was orally administered to male ICR mice, at 0.5, 1.0 and 2. 0 g/kg, 30 min before the behavioural evaluation in the black and white test (BWT) and elevated plus maze (EPM). The SZJE at the dosage 0.5-2.0 g/kg increased the first time entry, total changes and times spent in the white chamber of the BWT. The SZJE at the dosage 0.5-1.0 g/kg increased the percentage of time-spent and the percentage of arm entries in the open arms of the EPM and decreased the percentage of time-spent and the percentage of arm entries in the closed arms of the EPM. Furthermore, the SZJE at the dosage of 1. 0 g/kg prolonged the hexobarbital-induced sleeping time in mice and decreased the locomotor activity in rats. These results suggested that SZJE possessed anxiolytic effect at lower dose and sedative effect at higher dose.
Polygala
Polygala reduces anxiety with palpitations and prolongs sleep; it also helps with memory loss.
Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice.
Yao Y, Jia M, Wu JG, Zhang H, Sun LN, Chen WS, Rahman K. Pharm Biol. 2010 Jul;48(7):801-7. doi: 10.3109/13880200903280042.
In the present study, the anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia Willdenow (Polygalaceae) were determined in mice using hole-board, elevated plus maze, open field, and sodium pentobarbital-induced hypnosis tests. Moreover, the acute toxicity of polygalasaponins was also estimated in mice. Sixty minutes after p.o. administration of polygalasaponins (40, 80, 160 mg/kg) in mice, the central crossing counts and percentage of central/total ambulation significantly increased and the number of rearings and defecations was evidently inhibited in the open field test. Polygalasaponins also increased the head-dips of mice in the hole-board test and the time spent by mice in the open arms of the X-maze, prolonged sleep duration and shortened sleep latency in the test of synergetic effect on sodium pentobarbital (45 and 25 mg/kg, respectively). Acute toxic study showed the oral median lethal dose (LD(50)) of polygalasaponins was 3.95 g/kg and 0% lethal dose 2.6 g/kg. These results suggest that polygalasaponin possesses evident anxiolytic and sedative-hypnotic activities and has a relatively safe dose range, which supports the use of Polygala tenuifolia root as an anxiolytic and sedative-hypnotic drug in folk medicine.
Albizzia
Albizzia is a CNS suppressant and regulates Liver Qi to reduce irritability. Treats short temper, insomnia and PMS symptoms.
Sedative activity of two flavonol glycosides isolated form the flowers of Albizza julibrissin Durazz,
Kang, T.H. et al. Journal of Ethnopharmacology 71 92000) 321-323.
The flowers of Albizzia julibrissin are used as a sedative in oriental traditional medicine. The phytochemical study of this plant allowed the isolation of two flavonol glycosides, quercitrin (1) and isoquercitrin (2). The sedative activity of these compounds was evaluated, and both compounds 1 and 2 increased pentobarbital-induced sleeping time in dose-dependent manner in mice. These results support the use of the flowers of this plant as a sedative agent.
Eclipta
Eclipta reduces Yin Xu heat flushing and reduces night sweats. It reduces dizziness.
Anemone
Anemone improves mental function, treats forgetfulness and insomnia.
References
Pilerood, Shirin Adel; Prakash, Jamuna. Nutritional and Medicinal Properties of Valerian (Valerian Officinalis). International Journal of Food, Nutrition and Dietetics 1.1 (Jan-Apr 2013): 25-32.
Voung. VG, Bowyer. MC, Roach. P.D, L-Theanine: properties, synthesis and isolation from tea. Journal of the Science of Food and Agriculture. Vol. 19, pages 1931-1939 August 2011
Wagner H, et al. Coumestans as the main active principles of the liver drugs Eclipta alba and wedelia calendulacea." Planta Med Oct 1986;(5):370-4.
| Ingredients |
|---|
| Eclipta prostrata |
| Valeriana officinalis |
| Ziziphus jujuba |
| Passiflora incarnata |
| Polygala sibirica |
| Camellia sinensis (L-Theanine) |
| Matricaria chamomilla |
| Wolfiporia cocos |
| Albizziae julibrissin |
| Anemone altaica |
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
Fulnight
60 x 500 mg Capsules
Actions
Increases REM sleep
Brings sleep on faster
Decreases the degradation of GABA to sedate CNS and increases feelings of peacefulness
Has hypnotic effect
Synergistic effect with phenylalanine on central nervous system function
Indications
Insomnia, Acute and Chronic
Difficulty falling asleep
Frequent night-time urination (Nocturia)
Waking too early in the morning
Unrefreshing sleep
Suggested Use:
Adult dosage: 2 capsules, 3 hours before sleep
Caution:
Orally, Valerian can cause headache, excitability and uneasiness. Occasionally, Valerian may cause gastric discomfort, dry mouth, vivid dreams, and morning drowsiness. Orally, Passionflower can cause dizziness, confusion, and ataxia in some patients.
Warning:
Do not use with pregnancy, lactation, hypotension. Not suitable for children under 12 years of age.
Valerian
Valerian is used as a sedative-hypnotic for insomnia and as an anxiolytic (anxiety reducer) for restlessness and sleeping disorders associated with anxiety. It has also been used for mood disorders such as depression, infantile convulsions, mild tremors, epilepsy, and attention deficit-hyperactivity disorder (ADHD).
Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
Ziegler G ,Ploch M , Miettinen-Baumann A , Collet W. European Journal of Medical Research [01 Nov 2002, 7(11):480-486]
Patients aged 18 to 73 years and diagnosed with non-organic insomnia according to ICD-10 (F 51.0) were treated in a multicentre, double-blind, randomised parallel group comparison with either 600 mg/die valerian extract LI 156 (Sedonium) or 10 mg/die oxazepam taken for 6 weeks. A total of 202 outpatients with a mean duration of insomnia of 3.5 months at baseline were included at 24 study centres (general practices) in Germany. - Sleep quality (SQ) after 6 weeks measured by the Sleep Questionnaire B (SF-B; CIPS 1996) showed that 600 mg/die valerian extract LI 156 was at least as efficacious as a treatment with 10 mg/die oxazepam. Both treatments markedly increased sleep quality compared with baseline (p <0.01). The other SF-B subscales, i.e. feeling of refreshment after sleep (GES), psychic stability in the evening (PSYA), psychic exhaustion in the evening (PSYE), psychosomatic symptoms in the sleep phase (PSS), dream recall (TRME), and duration of sleep confirmed similar effects of both treatments. Clinical Global Impressions scale (CGI) and Global Assessment of Efficacy by investigator and patient, again, showed similar effects of both treatments. Adverse events occurred in 29 patients (28.4%) receiving valerian extract LI 156 and 36 patients (36.0%) under oxazepam, and were all rated mild to moderate. No serious adverse drug reactions were reported in either group. Most patients assessed their respective treatment as very good (82.8% in the valerian group, 73.4% in the oxazepam group). During the 6 week treatment phase Valerian extract LI 156 (Sedonium) 600 mg/die showed a comparable efficacy to 10 mg/die oxazepam in the therapy of non-organic insomnia.
Theanine
Theanine is the major amino acid found in green tea. Green tea contains 1% to 3% theanine. There is interest in using theanine to prevent and treat dementia. Theanine demonstrates a protective effect by decreasing ischemic neuronal death in the forebrains of animal models. The antagonistic effects of theanine on glutamate and N-methyl-D-aspartate (NMDA) receptors might provide neuroprotection.
There is also interest in using theanine for hypertension. Theanine affects catecholamine’s that can cause vasoconstriction and lead to elevations in blood pressure. In animal models, theanine decreases norepinephrine levels, decreases systolic and diastolic blood pressure, and suppresses the stimulatory effects of caffeine (Voung et al., 2011).
Chamomile Extract
Chamomile Extract is standardized to 1.2% apigenin. Chamomile Extract has a calming effect on smooth muscle tissue and nerves, and may be useful as a remedy for nervous stomach, insomnia, skin irritations, toothaches, indigestion, anxiety, fever, headache, pain, gas, and colic. Chamomile Extract gently reduces anxiety and can help induce sleep. It is excellent for relieving gas, colic and digestive upset due to stress and anxiety.
Chamomile: A herbal medicine of the past with bright future. Molecular medicine reports.
Srivastava JK, Shankar E, Gupta S. Chamomile: 2010;3(6):895-901. doi:10.3892/mmr.2010.377.
Chamomile is one of the most ancient medicinal herbs known to mankind. It is a member of Asteraceae/Compositae family and represented by two common varieties viz. German Chamomile (Chamomilla recutita) and Roman Chamomile (Chamaemelum nobile). The dried flowers of chamomile contain many terpenoids and flavonoids contributing to its medicinal properties. Chamomile preparations are commonly used for many human ailments such as hay fever, inflammation, muscle spasms, menstrual disorders, insomnia, ulcers, wounds, gastrointestinal disorders, rheumatic pain, and haemorrhoids. Essential oils of chamomile are used extensively in cosmetics and aromatherapy. Many different preparations of chamomile have been developed, the most popular of which is in the form of herbal tea consumed more than one million cups per day. In this review we describe the use of chamomile in traditional medicine with regard to evaluating its curative and preventive properties, highlight recent findings for its development as a therapeutic agent promoting human health.
Jujuboside
Jujuboside is a hypnotic and sedative. The seeds and leaves of Zizyphus spinosa exert an inhibiting effect on central nervous system function, while the fruits have a synergism with pentobarbital sodium and thiopental sodium on prolongation of sleep and sedation, and also decrease coordinated action. Jujuboside A exerts no inhibiting effect, but has a synergistic effect with phenylalanine on central nervous system function. Treats palpitations and insomnia as well as tranquilizing the mind.
Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety.
Peng WH, Hsieh MT, Lee YS, Lin YC, Liao J. J Ethnopharmacol. 2000 Oct;72(3):435-41.
The aim of the present study was to investigate the ethanolic extract of Semen Ziziphi jujuba (SZJE) induced anxiolytic effect. The SZJE was orally administered to male ICR mice, at 0.5, 1.0 and 2. 0 g/kg, 30 min before the behavioural evaluation in the black and white test (BWT) and elevated plus maze (EPM). The SZJE at the dosage 0.5-2.0 g/kg increased the first time entry, total changes and times spent in the white chamber of the BWT. The SZJE at the dosage 0.5-1.0 g/kg increased the percentage of time-spent and the percentage of arm entries in the open arms of the EPM and decreased the percentage of time-spent and the percentage of arm entries in the closed arms of the EPM. Furthermore, the SZJE at the dosage of 1. 0 g/kg prolonged the hexobarbital-induced sleeping time in mice and decreased the locomotor activity in rats. These results suggested that SZJE possessed anxiolytic effect at lower dose and sedative effect at higher dose.
Polygala
Polygala reduces anxiety with palpitations and prolongs sleep; it also helps with memory loss.
Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice.
Yao Y, Jia M, Wu JG, Zhang H, Sun LN, Chen WS, Rahman K. Pharm Biol. 2010 Jul;48(7):801-7. doi: 10.3109/13880200903280042.
In the present study, the anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia Willdenow (Polygalaceae) were determined in mice using hole-board, elevated plus maze, open field, and sodium pentobarbital-induced hypnosis tests. Moreover, the acute toxicity of polygalasaponins was also estimated in mice. Sixty minutes after p.o. administration of polygalasaponins (40, 80, 160 mg/kg) in mice, the central crossing counts and percentage of central/total ambulation significantly increased and the number of rearings and defecations was evidently inhibited in the open field test. Polygalasaponins also increased the head-dips of mice in the hole-board test and the time spent by mice in the open arms of the X-maze, prolonged sleep duration and shortened sleep latency in the test of synergetic effect on sodium pentobarbital (45 and 25 mg/kg, respectively). Acute toxic study showed the oral median lethal dose (LD(50)) of polygalasaponins was 3.95 g/kg and 0% lethal dose 2.6 g/kg. These results suggest that polygalasaponin possesses evident anxiolytic and sedative-hypnotic activities and has a relatively safe dose range, which supports the use of Polygala tenuifolia root as an anxiolytic and sedative-hypnotic drug in folk medicine.
Albizzia
Albizzia is a CNS suppressant and regulates Liver Qi to reduce irritability. Treats short temper, insomnia and PMS symptoms.
Sedative activity of two flavonol glycosides isolated form the flowers of Albizza julibrissin Durazz,
Kang, T.H. et al. Journal of Ethnopharmacology 71 92000) 321-323.
The flowers of Albizzia julibrissin are used as a sedative in oriental traditional medicine. The phytochemical study of this plant allowed the isolation of two flavonol glycosides, quercitrin (1) and isoquercitrin (2). The sedative activity of these compounds was evaluated, and both compounds 1 and 2 increased pentobarbital-induced sleeping time in dose-dependent manner in mice. These results support the use of the flowers of this plant as a sedative agent.
Eclipta
Eclipta reduces Yin Xu heat flushing and reduces night sweats. It reduces dizziness.
Anemone
Anemone improves mental function, treats forgetfulness and insomnia.
References
Pilerood, Shirin Adel; Prakash, Jamuna. Nutritional and Medicinal Properties of Valerian (Valerian Officinalis). International Journal of Food, Nutrition and Dietetics 1.1 (Jan-Apr 2013): 25-32.
Voung. VG, Bowyer. MC, Roach. P.D, L-Theanine: properties, synthesis and isolation from tea. Journal of the Science of Food and Agriculture. Vol. 19, pages 1931-1939 August 2011
Wagner H, et al. Coumestans as the main active principles of the liver drugs Eclipta alba and wedelia calendulacea." Planta Med Oct 1986;(5):370-4.