DysBio

$29.90
RV66

Dysbio contains a comprehensive blend of botanicals for upper and lower Gi complaints. Dysbiosis helps optimize healthy bacteria in the GI tract and relieves the symptoms caused by Dysbiosis.

Ingredients
Codonopsis pilosula
Atractylodes macrocephala
Wolfiporia cocos
Glycyrrhiza uralensis
Citrus reticulata
Pinellia ternate
Amomum villosum
Inula helenium

Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.

Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts

 DysBio

60 x 500 mg Capsules

Actions

Inhibits growth of gut pathogenic microorganisms

 Antibacterial

 Antifungal

 Promotes growth of friendly bacteria

 Repairs intestinal barrier

 Helps prevent increased intestinal permeability “Leaky gut”

Indications

 Dysbiosis

 Increased Intestinal permeability “leaky gut”

 SIBO

 IBS

 IBD

 Gluten sensitivity

Suggested Use: 

3-4 capsules, an hour before sleep

Caution: 

none noted

Warning: 

none noted

Dysbiosis

Abundant data have incriminated intestinal bacteria in the initiation and amplification stages of inflammatory bowel diseases (IBD). One theory has suggested a breakdown in the balance between putative species of “protective” versus “harmful” intestinal bacteria—this concept has been termed “dysbiosis”. (Tamboli et al., 2004).

Dysbiosis is the disruption of the normal balance of the trillions of microorganisms that populate the human intestinal tract. Those organisms occur in large communities, each of which should be as diverse as possible. Recent studies show that the greater the overall diversity among bacterial groups, the healthier the individual (Tojo et al., 2014; Jalanka-Tuovinen et al., 2014; Collins et al., 2009).

Gut dysbiosis can lead to physiological changes in the intestinal environment, disrupting the functions of the gut microbiota, autoimmune, allergic, metabolic and alcoholic liver diseases, irritable bowel syndrome, colorectal cancer, and bacterial infections have all been linked to dysbiosis.

Gluten sensitivity is a result of dysbiosis not a genetic disorder. Dysbiosis (also called dysbacteriosis) refers to a condition with microbial imbalances on or within the body.

Dysbiosis is most prominent in the digestive tract or on the skin, but can also occur on any exposed surface or mucous membrane such as the vagina, lungs, mouth, nose, sinuses, ears, nails, or eyes. It has been associated with different illnesses, like inflammatory bowel disease and chronic fatigue syndrome.

Codonopsis pilosula (Dang Shen)

Researchers found that Radix codonopsis fostered the growth of helpful bacteria, suppressed the growth of harmful bacteria, reduced bacterial translocation, controlled endotoxemia, and improved other relevant pathological and immunological targets.  Radix codonopsis can help prevent multiple organ dysfunction syndrome (MODS) by regulating intestinal dysbacteriosis (Wang et al., 2011).

Atractylodes macrocephala (Bai Zhu)

Qing qing et al (2016) studied the regulation effect on intestinal diagnostic flora of eight herbs including Atractylodis Macrocephalae Rhizoma. The multiplication results showed that Atractylodis Macrocephalae could promote the proliferation rate of Lactobacillus, significantly (P<0.05), and inhibited the multiplication of E. coli significantly (P<0.05)(Ye et al., 2016). 

Inula helenium (Mu Xiang)

O’Shea et al (2009) investigated the bactericidal activity (specifically anti-staphylococcal) of Inula helenium. The antimicrobial activity of Inula helenium extract was tested against 200 clinically significant Irish Staphylococcus aureus isolates consisting of methicillin-resistant (MRSA) and -sensitive (MSSA) S. aureus using a drop test method and a microbroth dilution method. Results proved I. helenium to be 100% effective against the 200 staphylococci tested, with 93% of isolates falling within the ++ and +++ groups. The extract was equally effective against antibiotic-resistant and -sensitive strains. This plant therefore possesses compounds with potent anti-staphylococcal properties, which in the future could be used to complement infection control policies and prevent staphylococcal infection and carriage. This research supports other studies wherein herbal plants exhibiting medicinal properties are being examined to overcome the problems of antibiotic resistance and to offer alternatives in the treatment and control of infectious diseases resistance and to offer alternatives in the treatment and control of infectious diseases (O'Shea et al., 2009).

Amomum villosum (Sha Ren)

The gastrointestinal motility of rats was markedly enhanced (P 0.01~0.05), the contents of Motilin (MTL), Substance P (SP) increased significantly (P 0.05~0.01), but the contents of VIP had not significant changes in plasma, antrum and jejunum tissue at 1 and 6 hours after Amomum Villosum extract was given. The above changes were more obvious at 1 hour than at 6 hour's. The kinetogenic effects of Amomum Villosum may be correlated to the increased contents of MTL and SP in plasma and gastrointestinal tract (Zhu et al., 2001).

A study of the antimicrobial and antioxidant effects of extract from Amomum villosum Lour showed that extract of A.villosum have different degrees of inhibition on Bacillus subtilis, Escherichia coli, Salmonella, Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumoniae. DPPH test showed that the extract had strong antioxidant. Extract of A.villosum ethyl acetate layer had the best antioxidant effects, and decreased the amount of DPPH(0.1 mmol/L) free radical to 13.99% when its concentration was 18 μg/mL, clearance rate was 86.01% (Tang et al., 2012).

References

Collins SM, Denou E, Verdu EF, Bercik P. The putative role of the intestinal microbiota in the irritable bowel syndrome. Dig Liver Dis. 2009 Dec;41(12):850-3.

Jalanka-Tuovinen J, Salojarvi J, Salonen A, et al. Fecal microbiota composition and host-microbe cross-talk following gastroenteritis and in post-infectious irritable bowel syndrome. Gut. 2014 Nov;63(11):1737-45.

O'Shea S, Lucey B, Cotter L. In vitro activity of Inula helenium against

clinical Staphylococcus aureus strains including MRSA. Br J Biomed Sci.

2009;66(4):186-9. PubMed PMID: 20095126.

Tamboli, C. P., et al. "Dysbiosis in inflammatory bowel disease." Gut 53.1 (2004): 1-4.

Tang JY, Liu FJ, Su MX, Huang Sf, Chen HY, (2012)  Study on antioxidant and antimicrobioal effect of extract from Amomum villosum. Journal of Xiuamen University Natural Science)

Tojo R, Suarez A, Clemente MG, et al. Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis. World J Gastroenterol. 2014 Nov 7;20(41):15163-76.

WANG Mo-lin, LI Xiao-guang, WANG Jian-jie, ZHANG Tao, YANG Jing-yun. Radix codonopsis mixture treats multiple organ dysfunction syndrome by adjusting intestinal tract dysbacteriosis and immunologic function. Zhong Guo Wei Sheng Tai Xue Za Zhi, 2011, (7): 586-588.

YE Qing qing, WANG Yaru, FANG Weibin, LIU Guangfeng, FENG Juan, GUAN Shuyu. Study on the regulation effect of 8 herbs on intestinal diagnostic flora growth. Guang Dong Yao Xue Yuan Xue Bao, 2016, (3): 291-294. 

Zhu, JZ. , Leng, E,. Chen., DF (2001) Effects of Amonum Villosum on Gastrointestinal Motility and Neurotransmitters in Rats. Chinese Journal of Integrated Traditional and Western Medicine.