Cruciferous
Cruciferous acts as an Aromatase inhibitor. Aromatase is an enzyme that synthesizes oestrogen. Aromatase inhibitors block the synthesis of oestrogen.
Cruciferous acts as an Aromatase inhibitor. Aromatase is an enzyme that synthesizes oestrogen. Aromatase inhibitors block the synthesis of oestrogen.
| Ingredients |
|---|
| Brassica oleracea l. (Broccoli) Super Concentrate Extract (flower bud) (std. to 4% glucosinolates) |
| Nasturtium officinale 5:1 Extract (leaf) |
| Uncaria tomentosa Extract (stem bark) (std. to 8% carboxy alkyl esters) |
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
Cruciferous
60 x 500 mg capsules
Actions
• Aromatase Inhibitor - lowers oestrogen levels by blocking synthesis of oestrogen *
Suggested Use:
1 to 2 capsules daily.* For best results add 10mg or more of DIM (Di-indolyl-methane) per capsule.
*One capsule daily for individuals weighing up to 160 pounds. Those weighing over 160 pounds, take two capsules daily.
Caution:
None Noted
Warning:
may interfere with oral contraceptives. If pregnant or intending to become pregnant, do not use this product. Do not use if taking antacids, H2-receptor blockers (e.g. Zantac), or proton-pump inhibitors (e.g. Nexium), as these drugs may impede the conversion of I3C to active metabolites.
Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomized controlled trials
Armah CN et al. Molecular Nutrition & Food Research 7 APR 2015 DOI: 10.1002/mnfr.201400863
Cruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables. This study tests the hypothesis that a diet rich in high glucoraphanin (HG) broccoli will reduce plasma LDL-C.
One hundred and thirty volunteers were recruited to two independent double-blind, randomly allocated parallel dietary intervention studies, and were assigned to consume either 400 g standard broccoli or 400 g HG broccoli per week for 12 weeks. Plasma lipids were quantified before and after the intervention. In study 1 (37 volunteers), the HG broccoli diet reduced plasma LDL-C by 7.1% (95% CI: –1.8%, –12.3%, p = 0.011), whereas standard broccoli reduced LDL-C by 1.8% (95% CI +3.9%, –7.5%, ns). In study 2 (93 volunteers), the HG broccoli diet resulted in a reduction of 5.1% (95% CI: –2.1%, –8.1%, p = 0.001), whereas standard broccoli reduced LDL-C by 2.5% (95% CI: +0.8%, –5.7%, ns). When data from the two studies were combined the reduction in LDL-C by the HG broccoli was significantly greater than standard broccoli (p = 0.031).
Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.
Carnosol (Rosemary)
Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. Carnosol treatment showed reduction of nuclear factor-kappaB (NF-kappaB) subunits translocation and NF-kappaB DNA binding activity in activated macrophages. Carnosol also showed inhibition of iNOS and NF-kappaB promoter activity in transient transfection assay.
Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages (Lo et al., 2002).
Di-Indoly Methane (DIM)
Di-Indoly Methane (DIM) is derived from cruciferous vegetables. It is the stable, bioavailable form of indole-3-carbinol (I3C), but with 10 times the potency of I3C.
Indole-3-carbinol (I3C)
Most ageing people (both men and women) are in estrogen overload. With the dangers associated with excess estrogen, Indole-3-carbinol (I3C) acts like an estrogen vacuum cleaner.
The process begins when I3C is ingested. Stomach acid converts it into a variety of products that ultimately induce the enzyme cytochrome P450, which signals the body to metabolize estrogen via the 2-hydroxylation pathway. By funneling estrogen into this pathway, I3C essentially "vacuums" away the estrogen (Michnovic & Bradlow, 1991).
Specific extracts from cruciferous vegetables (e.g. broccoli, cauliflower, brussel sprouts) have been identified that modulate hormones in a way to help maintain healthy cell division.
Di-indolyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone (Parkin & Malejka-Giganti, 2004).
The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce the expression of the beneficial p53 gene via an estrogen-independent action (Fimognari et al.,2002).
In addition, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone (Horn et a., 2002). Indole-3-carbinol also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals (Nho & Jeffery, 2001). Human studies support the beneficial role of I3C in positively altering estrogen metabolism.
Watercress
Watercress contains isothiocyanates, but in a broader spectrum than does broccoli. The primary isothiocyanate precursor (PEiTC) in watercress functions via four specific mechanisms to maintain healthy cell division (Zhang et al., 2003). Extracts from rosemary enhance liver metabolism of estradiol and estrone (Zhu et al., 1998), inhibits the formation of DNA adducts (Offord et al., 1995) and have been shown to impede estrogen-induced growth promotion in certain tissues (Zhu et al., 1998) .
Cats Claw
Cats Claw, the Amazonian "wonder herb", also known as Uncaria tomentosa or Ua de Gato, has been available for years, but there are various qualities of extracts. Cruciferous contains only Cats Claw water extract which has naturally occurring potent compounds called carboxy alkyl esters. These compounds, not found in typical Cats Claw products, have properties of DNA repair and anti-inflammation, and immune stimulation. Cat's claw protects cells against oxidative stress and inhibits lipopolysaccharide-induced iNOS gene expression, nitrite formation, cell death and inhibited the activation of NF-kappaB ( Sandoval-Chacón et al., 1998).
References
Fimognari C, Nüsse M, Cesari R, Iori R, Cantelli-Forti G, Hrelia P. (2002). Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis, 23(4):581-6. PubMed PMID: 11960909.
Horn TL, Reichert MA, Bliss RL, Malejka-Giganti D. Modulations of P450 mRNA in liver and mammary gland and P450 activities and metabolism of estrogen in liver by treatment of rats with indole-3-carbinol. Biochem Pharm. 2002, 64;393-404.
Lo AH, Liang YC, Lin-Shiau SY, Ho CT, Lin JK. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis. 2002 Jun;23(6):983-91.
Michnovicz JJ, Bradlow HL. Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol. Nutr Cancer. 1991;16 (1): 59-66
Nho CW, Jeffery E. (2001). The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables. Toxicol Appl Pharmacol, 174(2):146-52. PubMed PMID: 11446830.
Offord EA, Macé K, Ruffieux C, Malnoë A, Pfeifer AM. (1995). Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells. Carcinogenesis, 16(9):2057-62. PubMed PMID: 7554054.
Parkin DR, Malejka-Giganti D. (2004). Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol. Cancer Detect Prev, 28(1):72-9. PubMed PMID: 15041081.
Sandoval-Chacón M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sadowska-Krowicka H, Charbonnet RM, Clark DA, Miller MJ. (1998). Antiinflammatory actions of cat's claw: the role of NF-kappaB. Aliment Pharmacol Ther, 12(12):1279-89.
Zhang Y, Tang L, Gonzalez V. Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol Cancer Ther. 2003 Oct;2(10);1045-52.
Zhu BT, Loder DP, Cai MX, Ho CT, Huang MT, Conney AH. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis. 1998 Oct;19(10):1821-7.
Cruciferous acts as an Aromatase inhibitor. Aromatase is an enzyme that synthesizes oestrogen. Aromatase inhibitors block the synthesis of oestrogen.
| Ingredients |
|---|
| Brassica oleracea l. (Broccoli) Super Concentrate Extract (flower bud) (std. to 4% glucosinolates) |
| Nasturtium officinale 5:1 Extract (leaf) |
| Uncaria tomentosa Extract (stem bark) (std. to 8% carboxy alkyl esters) |
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
Cruciferous
60 x 500 mg capsules
Actions
• Aromatase Inhibitor - lowers oestrogen levels by blocking synthesis of oestrogen *
Suggested Use:
1 to 2 capsules daily.* For best results add 10mg or more of DIM (Di-indolyl-methane) per capsule.
*One capsule daily for individuals weighing up to 160 pounds. Those weighing over 160 pounds, take two capsules daily.
Caution:
None Noted
Warning:
may interfere with oral contraceptives. If pregnant or intending to become pregnant, do not use this product. Do not use if taking antacids, H2-receptor blockers (e.g. Zantac), or proton-pump inhibitors (e.g. Nexium), as these drugs may impede the conversion of I3C to active metabolites.
Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomized controlled trials
Armah CN et al. Molecular Nutrition & Food Research 7 APR 2015 DOI: 10.1002/mnfr.201400863
Cruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables. This study tests the hypothesis that a diet rich in high glucoraphanin (HG) broccoli will reduce plasma LDL-C.
One hundred and thirty volunteers were recruited to two independent double-blind, randomly allocated parallel dietary intervention studies, and were assigned to consume either 400 g standard broccoli or 400 g HG broccoli per week for 12 weeks. Plasma lipids were quantified before and after the intervention. In study 1 (37 volunteers), the HG broccoli diet reduced plasma LDL-C by 7.1% (95% CI: –1.8%, –12.3%, p = 0.011), whereas standard broccoli reduced LDL-C by 1.8% (95% CI +3.9%, –7.5%, ns). In study 2 (93 volunteers), the HG broccoli diet resulted in a reduction of 5.1% (95% CI: –2.1%, –8.1%, p = 0.001), whereas standard broccoli reduced LDL-C by 2.5% (95% CI: +0.8%, –5.7%, ns). When data from the two studies were combined the reduction in LDL-C by the HG broccoli was significantly greater than standard broccoli (p = 0.031).
Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.
Carnosol (Rosemary)
Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. Carnosol treatment showed reduction of nuclear factor-kappaB (NF-kappaB) subunits translocation and NF-kappaB DNA binding activity in activated macrophages. Carnosol also showed inhibition of iNOS and NF-kappaB promoter activity in transient transfection assay.
Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages (Lo et al., 2002).
Di-Indoly Methane (DIM)
Di-Indoly Methane (DIM) is derived from cruciferous vegetables. It is the stable, bioavailable form of indole-3-carbinol (I3C), but with 10 times the potency of I3C.
Indole-3-carbinol (I3C)
Most ageing people (both men and women) are in estrogen overload. With the dangers associated with excess estrogen, Indole-3-carbinol (I3C) acts like an estrogen vacuum cleaner.
The process begins when I3C is ingested. Stomach acid converts it into a variety of products that ultimately induce the enzyme cytochrome P450, which signals the body to metabolize estrogen via the 2-hydroxylation pathway. By funneling estrogen into this pathway, I3C essentially "vacuums" away the estrogen (Michnovic & Bradlow, 1991).
Specific extracts from cruciferous vegetables (e.g. broccoli, cauliflower, brussel sprouts) have been identified that modulate hormones in a way to help maintain healthy cell division.
Di-indolyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone (Parkin & Malejka-Giganti, 2004).
The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce the expression of the beneficial p53 gene via an estrogen-independent action (Fimognari et al.,2002).
In addition, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone (Horn et a., 2002). Indole-3-carbinol also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals (Nho & Jeffery, 2001). Human studies support the beneficial role of I3C in positively altering estrogen metabolism.
Watercress
Watercress contains isothiocyanates, but in a broader spectrum than does broccoli. The primary isothiocyanate precursor (PEiTC) in watercress functions via four specific mechanisms to maintain healthy cell division (Zhang et al., 2003). Extracts from rosemary enhance liver metabolism of estradiol and estrone (Zhu et al., 1998), inhibits the formation of DNA adducts (Offord et al., 1995) and have been shown to impede estrogen-induced growth promotion in certain tissues (Zhu et al., 1998) .
Cats Claw
Cats Claw, the Amazonian "wonder herb", also known as Uncaria tomentosa or Ua de Gato, has been available for years, but there are various qualities of extracts. Cruciferous contains only Cats Claw water extract which has naturally occurring potent compounds called carboxy alkyl esters. These compounds, not found in typical Cats Claw products, have properties of DNA repair and anti-inflammation, and immune stimulation. Cat's claw protects cells against oxidative stress and inhibits lipopolysaccharide-induced iNOS gene expression, nitrite formation, cell death and inhibited the activation of NF-kappaB ( Sandoval-Chacón et al., 1998).
References
Fimognari C, Nüsse M, Cesari R, Iori R, Cantelli-Forti G, Hrelia P. (2002). Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis, 23(4):581-6. PubMed PMID: 11960909.
Horn TL, Reichert MA, Bliss RL, Malejka-Giganti D. Modulations of P450 mRNA in liver and mammary gland and P450 activities and metabolism of estrogen in liver by treatment of rats with indole-3-carbinol. Biochem Pharm. 2002, 64;393-404.
Lo AH, Liang YC, Lin-Shiau SY, Ho CT, Lin JK. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis. 2002 Jun;23(6):983-91.
Michnovicz JJ, Bradlow HL. Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol. Nutr Cancer. 1991;16 (1): 59-66
Nho CW, Jeffery E. (2001). The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables. Toxicol Appl Pharmacol, 174(2):146-52. PubMed PMID: 11446830.
Offord EA, Macé K, Ruffieux C, Malnoë A, Pfeifer AM. (1995). Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells. Carcinogenesis, 16(9):2057-62. PubMed PMID: 7554054.
Parkin DR, Malejka-Giganti D. (2004). Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol. Cancer Detect Prev, 28(1):72-9. PubMed PMID: 15041081.
Sandoval-Chacón M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sadowska-Krowicka H, Charbonnet RM, Clark DA, Miller MJ. (1998). Antiinflammatory actions of cat's claw: the role of NF-kappaB. Aliment Pharmacol Ther, 12(12):1279-89.
Zhang Y, Tang L, Gonzalez V. Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol Cancer Ther. 2003 Oct;2(10);1045-52.
Zhu BT, Loder DP, Cai MX, Ho CT, Huang MT, Conney AH. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis. 1998 Oct;19(10):1821-7.