CNS Factor (NeuroFactor)
120 x 500 mg Capsules
Actions
Anti-depressant
Anxiolytic
Adaptogen
Reduces effects of stress
Improves memory, cognition and attention
Regulates heathy sleep cycle
Increases Brain-derived neurotrophic Factors (BDNF)
Regulates stress hormone production
Reduces serum levels of cortistatin, adrenocorticotropic hormone (ACTH), and corticotropin-releasing factor (CRF)
Upregulates GABAA receptors
Reduces glutamic acid levels
Increases serotonin
Indications
Depression (Treatment-Resistant Depression (TRD))
Anxiety
Chronic stress
Stress related memory impairment
Cognitive impairment
Neurodegenerative conditions
Suggested use: 3-4 capsules daily
Cautions and Contraindications
Caution in pregnancy.
Schisandra may affect medications metabolized by the liver enzymes Cytochrome P450 1A2, 2C9, 3A4, and 3A5 substrates: medications changed by the liver include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and warfarin (Coumadin). The doses of the medication might need to be changed.
Schisandra may have inhibitory effects on the liver enzyme Cytochrome P450 3A4. Medications metabolized by CYP 450 3A4 include Alprazolam (Xanax), amlodipine (Norvasc), atorvastatin (Lipitor), cyclosporine (Sandimmune), diazepam (Valium), estradiol (Estrace), simvastatin (Zocor), sildenafil (Viagra), verapamil, zolpidem (Ambien)
Warfarin (Coumadin) interacts with schisandra: Warfarin (Coumadin) is used to slow blood clotting. The body breaks down warfarin (Coumadin) to get rid of it. Schisandra might increase the breakdown and decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
Anti-epileptic drugs: Benzodiazepines are one of the most common. NeuroFactor is an agonist and will cause drowsiness, and therefore needs to be monitored.
May increase effect of Benzodiazepine drugs however, it’s not contraindicated. Schisandra has been used for Benzodiazepine withdrawal.
Supports SSRIs.
P-glycoprotein substrates: Lab and human studies suggest schisandra can inhibit Pgp activity and may interfere with the metabolism of certain drugs.
Tacrolimus: In liver transplant patients, schisandra increased blood levels of tacrolimus, an immunosuppressant.