CNS Factor

CNS Factor

$40.30
RV105

The combination of herbs in CNS Factor increase Brain Derived Neurotrophic Factor (BDNF). A key ingredient, Schisandrin B, has well-known adaptogenic, cognitive, neuro-protective, mood balancing and anti-inflammatory effects.

CNS Factor combination has been researched increase Brain-derived neurotrophic factor (BDNF) levels in the brain. A key ingredient Schisandrin B a well-known adaptogen, cognitive aid, neuroprotective, mood balancing and anti-inflammatory effects.*

Ingredients

Euphoria longana

Houttuynia cordata

Dioscorea japonica

Schisandra Chinensis (Schisandrin B) (extract 35:1),


Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.

Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts.

CNS Factor (NeuroFactor)

120 x 500 mg Capsules

Actions

Anti-depressant

Anxiolytic

Adaptogen

Reduces effects of stress

Improves memory, cognition and attention

Regulates heathy sleep cycle

Increases Brain-derived neurotrophic Factors (BDNF)

Regulates stress hormone production

Reduces serum levels of cortistatin, adrenocorticotropic hormone (ACTH), and corticotropin-releasing factor (CRF)

Upregulates GABAA receptors

Reduces glutamic acid levels

Increases serotonin

Indications

Depression (Treatment-Resistant Depression (TRD))

Anxiety

Chronic stress

Stress related memory impairment

Cognitive impairment

Neurodegenerative conditions

Suggested use: 3-4 capsules daily

Cautions and Contraindications

Caution in pregnancy.

Schisandra may affect medications metabolized by the liver enzymes Cytochrome P450 1A2, 2C9, 3A4, and 3A5 substrates: medications changed by the liver include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and warfarin (Coumadin). The doses of the medication might need to be changed.

Schisandra may have inhibitory effects on the liver enzyme Cytochrome P450 3A4. Medications metabolized by CYP 450 3A4 include Alprazolam (Xanax), amlodipine (Norvasc), atorvastatin (Lipitor), cyclosporine (Sandimmune), diazepam (Valium), estradiol (Estrace), simvastatin (Zocor), sildenafil (Viagra), verapamil, zolpidem (Ambien)

Warfarin (Coumadin) interacts with schisandra: Warfarin (Coumadin) is used to slow blood clotting. The body breaks down warfarin (Coumadin) to get rid of it. Schisandra might increase the breakdown and decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Anti-epileptic drugs: Benzodiazepines are one of the most common. NeuroFactor is an agonist and will cause drowsiness, and therefore needs to be monitored.

May increase effect of Benzodiazepine drugs however, it’s not contraindicated. Schisandra has been used for Benzodiazepine withdrawal.

Supports SSRIs.

P-glycoprotein substrates: Lab and human studies suggest schisandra can inhibit Pgp activity and may interfere with the metabolism of certain drugs.

Tacrolimus: In liver transplant patients, schisandra increased blood levels of tacrolimus, an immunosuppressant.

CNS FACTOR

Research Article

Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors.

The extracts from Schisandra chinensis fructus have been reported to possess a variety of pharmacological effects on CNS disorders. These effects include neuroprotection, improvement of learning and memory, sedative-hypnotic, anxiolytic, and antidepressant effects. Due to its high availability in the brain after administration, SchB possessed multiple neuroprotective effects, sedative and hypnotic properties.

Research Article

Effects of schisandrin B on hypoxia-related cognitive function and protein expression in vascular dementia rats

Schisandrin B (Sch B) an active component derived from Chinese herb Wuweizi prevented β-amyloid protein induced morphological alterations and cell death using a SH-SY5Y neuronal cells considered an AD model. It was thus of interest to determine whether Sch B might also alleviate VD using a rat bilateral common carotid artery occlusion (BCAO) dementia model.

The results showed that Sch B improved learning and memory function of rats with VD and exerted a protective effect on the hippocampus by inhibition of protein expression of HIF-1α, TRAK2, and HUMMR factors. Evidence indicates that Sch B may be considered as an alternative in VD treatment.