Berberine Complex
Panaxea’s Berberine Complex can be used in a broad range of treatment protocols, including Oncology, PCOS and SIBO. Berberine benefits include: maintaining healthy cholesterol levels and glucose levels; eradicating unhealthy bacteria from the GI tract and reducing chronic inflammation.
Panaxea’s Berberine Complex can be used in a broad range of treatment protocols, including Oncology and SIBO. Berberine benefits include: maintaining healthy cholesterol levels and glucose levels; eradicating unhealthy bacteria from the GI tract and reducing chronic inflammation.*
| Ingredients |
|---|
| Coptis chinensis (contains Berberine) |
| Corydalis (methanol extract Corydalis Tuber alkaloids (10%) |
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
Berberine Complex
60 x 500 mg Capsules
Actions
• Anti-inflammatory
• Anti-oxidative
• Anti-diabetic
• Reduces fasting plasma glucose
• Lowers cholesterol and triglycerides
• Eliminates pathogenic bacteria in gastrointestinal tract
• Helps repair mucosal lining
• Promotes recovery in colitis
• Inhibits pro-inflammatory response in colonic macrophages and epithelial cells
• Radio-sensitizer
• Cell-cycle arrest
• Angiogenesis
• Chemo-enhancing
• Anti-metastatic
• Pro-apoptotic
Indications
• Chronic Systemic inflammation
• PCOS
• Hyperlipidaemia
• Type II Diabetes
• Small intestinal bacteria overgrowth (SIBO)
• IBS-D
• Cancer support
Suggested Use
Adult dosage: 2 caps 2 times daily on empty stomach. For optimal absorption and long term use add ProB)Plus (1 scoop a day)
For treatment of systemic inflammation alternate with ICC every 6 weeks (2 x 2 caps daily)
For SIBO
–To clear mucosal inflammation and restore bowel function Add Gut Clear (2-3 caps twice daily)
–To heal leaky gut and Inhibit return of pathogenic bacteria and fungi - add Dysbio (3-4 caps before sleep) and Prebiotic Mix (1 scoop daily in juice, water or yogurt)
–For constipation-predominant SIBO add Freely Moving (2-4 caps in the morning on empty stomach)
Warning:
Do not use during pregnancy or lactation
Berberine (BBR)
Enhances antibiotic resistance by inhibiting the biofilm formation. 1
BBR has the potential to augment the effectiveness of antibiotics by modulating host immunity or by restoring the host’s gut microbiota to modulate its inflammatory response to infection. 1
Met(S) - Improves liver enzymes, lipid profile, and insulin sensitivity in non-alcoholic liver disease (NAFLD) patients. 2
Inflammatory acne, antimicrobial and anti-inflammatory properties. 3
BBR as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria. 3
Improves fertility in women with PCOS. 4
BBR is the only botanical compound included in European guidelines for the management of dyslipidaemia, and it is also used in patients who cannot tolerate statins. 5
Alleviates neurodegenerative diseases by regulating neuroinflammation and autophagy. 6
Berberine Antibiotic /Adjunct Multi Drug Resistance (MDR) extensive drug resistance (XDR)
Potentiation and Mechanism of Berberine as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria.
The growing global apprehension towards multi-drug resistant (MDR) bacteria necessitates the development of innovative strategies to combat these infections. Berberine (BER), an isoquinoline quaternary alkaloid derived from various medicinal plants, has surfaced as a promising antibiotic adjuvant due to its ability to enhance the effectiveness of conventional antibiotics against drug-resistant bacterial strains. (Zhou et al., 2023) review properties and mechanisms of BER as an adjunctive antibiotic against MDR bacteria. BER has been observed to exhibit synergistic effects when co-administered with a range of antibiotics, including β-lactams, quinolones, aminoglycosides, tetracyclines, macrolides, lincosamides and fusidic acid.
Modern pharmacological research has demonstrated that BER exhibits inhibitory effects on a broad range of Gram-positive and Gram-negative bacteria, rendering it effective in treating gastrointestinal infections and bacterial dysentery.
BER has been reported to exhibit synergistic effects with the carbapenem antibiotic imipenem, the macrolide antibiotic azithromycin, and several aminoglycoside antibiotics in vitro susceptibility tests against multi-drug resistance (MDR) or extensive drug resistance (XDR) P. aeruginosa.
Abstracts
Berberine—A Promising Therapeutic Approach to Polycystic Ovary Syndrome in Infertile/Pregnant Women
Life (Basel). 2023 Jan 2;13(1):125. doi:10.3390/life13010125
"Berberine is an alkaloid with a high concentration in various medicinal herbs that exhibits a hypoglycaemic effect alongside a broad range of other therapeutic activities. Its medical benefits may stand up for treating different conditions, including diabetes mellitus. So far, a small number of pharmacological/clinical trials available in the English language draw attention towards the good results of berberine’s use in PCOS women with insulin resistance for improving fertility and pregnancy outcomes."
Polycystic ovary syndrome management: a review of the possible amazing role of berberine.
Archives of Gynecology and Obstetrics https://doi.org/10.1007/s00404-020-05450-4
"Berberine induced a redistribution of adipose tissue, reducing VAT in the absence of weight loss and improved insulin sensitivity, quite like metformin. One author dem- onstrated that berberine improved the lipid pattern. Moreover, three authors demonstrated that berberine improved insulin resistance in theca cells with an improvement of the ovulation rate per cycle, so berberine is also effective on fertility and live birth rates."
Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome.
Front Nutr. 2025 Jan 14:11:1494348. DOI: 10.3389/fnut.2024.1494348
"Berberine increased jejunal villus height, villus/crypt ratio, mucosal thickness (P < 0.05), and goblet cell numbers in the villi and crypts (P < 0.05). Furthermore, berberine increased the optical density of mucin 2 and the mucin 2, P-glycoprotein, and CYP3A4 mRNA expression levels (P < 0.05). Berberine increased the expressions of zonula occludins-1 (ZO-1), zonula occludins-2 (ZO-2), Claudin-1, Occludin, and E-cadherin in the ileum (P < 0.05). Moreover, berberine increased the expression of BCL2, reduced intestinal epithelial cell apoptosis (P < 0.05) and decreased the expression of BAX and BAK in the duodenum and jejunum, as well as that of CASP3 and CASP9 in the duodenum and ileum (P < 0.05). Berberine decreased the expression of IL-1β, IL-6, IL-8, TNF-α, and IFN-γ (P < 0.05) and elevated total volatile fatty acids, acetic acid, propionic acid, valeric acid, and isovaleric acid concentrations (P < 0.05). Notably, berberine enhanced the abundance of beneficial bacteria including Enterococcus, Holdemanella, Weissella, Pediococcus, Muribaculum, Colidextribacter, Agathobacter, Roseburia, Clostridium, Fusicatenibacter, and Bifidobacterium. Simultaneously, the relative abundance of harmful and pathogenic bacteria, such as Prevotella, Paraprevotella, Corynebacterium, Catenisphaera, Streptococcus, Enterobacter, and Collinsella, decreased (P < 0.05)."
References
- Zhou, H., Wang, W., Cai, L., & Yang, T. (2023). Potentiation and Mechanism of Berberine as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria. Infect Drug Resist, 16, 7313-7326.
- Nie, Q., Li, M., Huang, C., Yuan, Y., Liang, Q., Ma, X., Qiu, T., & Li, J. (2024). The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review. Journal of Translational Medicine, 22(1), 225.
- Berberine shows antimicrobial and anti-inflammatory properties in inflammatory acne.3 Sun, L., Yu, Q., Peng, F., Sun, C., Wang, D., Pu, L., Xiong, F., Tian, Y., Peng, C., & Zhou, Q. (2023). The antibacterial activity of berberine against Cutibacterium acnes: its therapeutic potential in inflammatory acne. Front Microbiol, 14, 1276383.
- Xie, L., Zhang, D., Ma, H., He, H., Xia, Q., Shen, W., Chang, H., Deng, Y., Wu, Q., Cong, J., Wang, C. C., & Wu, X. (2019). The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials. Evid Based Complement Alternat Med, 2019, 7918631.
- Rondanelli, M., Infantino, V., Riva, A., Petrangolini, G., Faliva, M. A., Peroni, G., Naso, M., Nichetti, M., Spadaccini, D., Gasparri, C., & Perna, S. (2020). Polycystic ovary syndrome management: a review of the possible amazing role of berberine. Arch Gynecol Obstet, 301(1), 53-60.
- Sunhe YX, Zhang YH, Fu RJ, Xu DQ, Tang YP. Neuroprotective effect and preparation methods of berberine. Front Pharmacol. 2024 Sep 6;15:1429050. doi:10.3389/fphar.2024.1429050. PMID: 39309003; PMCID: PMC11412855
Panaxea’s Berberine Complex can be used in a broad range of treatment protocols, including Oncology and SIBO. Berberine benefits include: maintaining healthy cholesterol levels and glucose levels; eradicating unhealthy bacteria from the GI tract and reducing chronic inflammation.*
| Ingredients |
|---|
| Coptis chinensis (contains Berberine) |
| Corydalis (methanol extract Corydalis Tuber alkaloids (10%) |
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
Berberine Complex
60 x 500 mg Capsules
Actions
• Anti-inflammatory
• Anti-oxidative
• Anti-diabetic
• Reduces fasting plasma glucose
• Lowers cholesterol and triglycerides
• Eliminates pathogenic bacteria in gastrointestinal tract
• Helps repair mucosal lining
• Promotes recovery in colitis
• Inhibits pro-inflammatory response in colonic macrophages and epithelial cells
• Radio-sensitizer
• Cell-cycle arrest
• Angiogenesis
• Chemo-enhancing
• Anti-metastatic
• Pro-apoptotic
Indications
• Chronic Systemic inflammation
• PCOS
• Hyperlipidaemia
• Type II Diabetes
• Small intestinal bacteria overgrowth (SIBO)
• IBS-D
• Cancer support
Suggested Use
Adult dosage: 2 caps 2 times daily on empty stomach. For optimal absorption and long term use add ProB)Plus (1 scoop a day)
For treatment of systemic inflammation alternate with ICC every 6 weeks (2 x 2 caps daily)
For SIBO
–To clear mucosal inflammation and restore bowel function Add Gut Clear (2-3 caps twice daily)
–To heal leaky gut and Inhibit return of pathogenic bacteria and fungi - add Dysbio (3-4 caps before sleep) and Prebiotic Mix (1 scoop daily in juice, water or yogurt)
–For constipation-predominant SIBO add Freely Moving (2-4 caps in the morning on empty stomach)
Warning:
Do not use during pregnancy or lactation
Berberine (BBR)
Enhances antibiotic resistance by inhibiting the biofilm formation. 1
BBR has the potential to augment the effectiveness of antibiotics by modulating host immunity or by restoring the host’s gut microbiota to modulate its inflammatory response to infection. 1
Met(S) - Improves liver enzymes, lipid profile, and insulin sensitivity in non-alcoholic liver disease (NAFLD) patients. 2
Inflammatory acne, antimicrobial and anti-inflammatory properties. 3
BBR as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria. 3
Improves fertility in women with PCOS. 4
BBR is the only botanical compound included in European guidelines for the management of dyslipidaemia, and it is also used in patients who cannot tolerate statins. 5
Alleviates neurodegenerative diseases by regulating neuroinflammation and autophagy. 6
Berberine Antibiotic /Adjunct Multi Drug Resistance (MDR) extensive drug resistance (XDR)
Potentiation and Mechanism of Berberine as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria.
The growing global apprehension towards multi-drug resistant (MDR) bacteria necessitates the development of innovative strategies to combat these infections. Berberine (BER), an isoquinoline quaternary alkaloid derived from various medicinal plants, has surfaced as a promising antibiotic adjuvant due to its ability to enhance the effectiveness of conventional antibiotics against drug-resistant bacterial strains. (Zhou et al., 2023) review properties and mechanisms of BER as an adjunctive antibiotic against MDR bacteria. BER has been observed to exhibit synergistic effects when co-administered with a range of antibiotics, including β-lactams, quinolones, aminoglycosides, tetracyclines, macrolides, lincosamides and fusidic acid.
Modern pharmacological research has demonstrated that BER exhibits inhibitory effects on a broad range of Gram-positive and Gram-negative bacteria, rendering it effective in treating gastrointestinal infections and bacterial dysentery.
BER has been reported to exhibit synergistic effects with the carbapenem antibiotic imipenem, the macrolide antibiotic azithromycin, and several aminoglycoside antibiotics in vitro susceptibility tests against multi-drug resistance (MDR) or extensive drug resistance (XDR) P. aeruginosa.
Abstracts
Berberine—A Promising Therapeutic Approach to Polycystic Ovary Syndrome in Infertile/Pregnant Women
Life (Basel). 2023 Jan 2;13(1):125. doi:10.3390/life13010125
"Berberine is an alkaloid with a high concentration in various medicinal herbs that exhibits a hypoglycaemic effect alongside a broad range of other therapeutic activities. Its medical benefits may stand up for treating different conditions, including diabetes mellitus. So far, a small number of pharmacological/clinical trials available in the English language draw attention towards the good results of berberine’s use in PCOS women with insulin resistance for improving fertility and pregnancy outcomes."
Polycystic ovary syndrome management: a review of the possible amazing role of berberine.
Archives of Gynecology and Obstetrics https://doi.org/10.1007/s00404-020-05450-4
"Berberine induced a redistribution of adipose tissue, reducing VAT in the absence of weight loss and improved insulin sensitivity, quite like metformin. One author dem- onstrated that berberine improved the lipid pattern. Moreover, three authors demonstrated that berberine improved insulin resistance in theca cells with an improvement of the ovulation rate per cycle, so berberine is also effective on fertility and live birth rates."
Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome.
Front Nutr. 2025 Jan 14:11:1494348. DOI: 10.3389/fnut.2024.1494348
"Berberine increased jejunal villus height, villus/crypt ratio, mucosal thickness (P < 0.05), and goblet cell numbers in the villi and crypts (P < 0.05). Furthermore, berberine increased the optical density of mucin 2 and the mucin 2, P-glycoprotein, and CYP3A4 mRNA expression levels (P < 0.05). Berberine increased the expressions of zonula occludins-1 (ZO-1), zonula occludins-2 (ZO-2), Claudin-1, Occludin, and E-cadherin in the ileum (P < 0.05). Moreover, berberine increased the expression of BCL2, reduced intestinal epithelial cell apoptosis (P < 0.05) and decreased the expression of BAX and BAK in the duodenum and jejunum, as well as that of CASP3 and CASP9 in the duodenum and ileum (P < 0.05). Berberine decreased the expression of IL-1β, IL-6, IL-8, TNF-α, and IFN-γ (P < 0.05) and elevated total volatile fatty acids, acetic acid, propionic acid, valeric acid, and isovaleric acid concentrations (P < 0.05). Notably, berberine enhanced the abundance of beneficial bacteria including Enterococcus, Holdemanella, Weissella, Pediococcus, Muribaculum, Colidextribacter, Agathobacter, Roseburia, Clostridium, Fusicatenibacter, and Bifidobacterium. Simultaneously, the relative abundance of harmful and pathogenic bacteria, such as Prevotella, Paraprevotella, Corynebacterium, Catenisphaera, Streptococcus, Enterobacter, and Collinsella, decreased (P < 0.05)."
References
- Zhou, H., Wang, W., Cai, L., & Yang, T. (2023). Potentiation and Mechanism of Berberine as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria. Infect Drug Resist, 16, 7313-7326.
- Nie, Q., Li, M., Huang, C., Yuan, Y., Liang, Q., Ma, X., Qiu, T., & Li, J. (2024). The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review. Journal of Translational Medicine, 22(1), 225.
- Berberine shows antimicrobial and anti-inflammatory properties in inflammatory acne.3 Sun, L., Yu, Q., Peng, F., Sun, C., Wang, D., Pu, L., Xiong, F., Tian, Y., Peng, C., & Zhou, Q. (2023). The antibacterial activity of berberine against Cutibacterium acnes: its therapeutic potential in inflammatory acne. Front Microbiol, 14, 1276383.
- Xie, L., Zhang, D., Ma, H., He, H., Xia, Q., Shen, W., Chang, H., Deng, Y., Wu, Q., Cong, J., Wang, C. C., & Wu, X. (2019). The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials. Evid Based Complement Alternat Med, 2019, 7918631.
- Rondanelli, M., Infantino, V., Riva, A., Petrangolini, G., Faliva, M. A., Peroni, G., Naso, M., Nichetti, M., Spadaccini, D., Gasparri, C., & Perna, S. (2020). Polycystic ovary syndrome management: a review of the possible amazing role of berberine. Arch Gynecol Obstet, 301(1), 53-60.
- Sunhe YX, Zhang YH, Fu RJ, Xu DQ, Tang YP. Neuroprotective effect and preparation methods of berberine. Front Pharmacol. 2024 Sep 6;15:1429050. doi:10.3389/fphar.2024.1429050. PMID: 39309003; PMCID: PMC11412855