Berberine (BBR): “One-drug with multiple mechanisms and multiple targets”

Berberine (BBR) enhances antibiotic resistance by inhibiting the biofilm formation. 1

 
Berberine (BBR) has the potential to augment the effectiveness of antibiotics by modulating host immunity or by restoring the host’s gut microbiota to modulate its inflammatory response to infection. 1
 
Berberine (BBR) - Met(S) Improves liver enzymes, lipid profile, and insulin sensitivity in non-alcoholic liver disease (NAFLD) patients. 2
 
Berberine (BBR) Inflammatory acne, antimicrobial and anti-inflammatory properties. 3
 
Berberine (BBR) as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria. 3
 
Berberine (BBR) improves fertility in women with PCOS. 4
 
Berberine (BBR) is the only botanical compound included in European guidelines for the management of dyslipidaemia, and it is also used in patients who cannot tolerate statins. 5
 
Berberine (BBR) alleviates neurodegenerative diseases by regulating neuroinflammation and autophagy. 6

 

References

 

  1. Zhou, H., Wang, W., Cai, L., & Yang, T. (2023). Potentiation and Mechanism of Berberine as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria. Infect Drug Resist, 16, 7313-7326.
  2. Nie, Q., Li, M., Huang, C., Yuan, Y., Liang, Q., Ma, X., Qiu, T., & Li, J. (2024). The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review. Journal of Translational Medicine, 22(1), 225.
  3. Berberine shows antimicrobial and anti-inflammatory properties in inflammatory acne.3 Sun, L., Yu, Q., Peng, F., Sun, C., Wang, D., Pu, L., Xiong, F., Tian, Y., Peng, C., & Zhou, Q. (2023). The antibacterial activity of berberine against Cutibacterium acnes: its therapeutic potential in inflammatory acne. Front Microbiol, 14, 1276383.
  4. Xie, L., Zhang, D., Ma, H., He, H., Xia, Q., Shen, W., Chang, H., Deng, Y., Wu, Q., Cong, J., Wang, C. C., & Wu, X. (2019). The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials. Evid Based Complement Alternat Med, 2019, 7918631.
  5. Rondanelli, M., Infantino, V., Riva, A., Petrangolini, G., Faliva, M. A., Peroni, G., Naso, M., Nichetti, M., Spadaccini, D., Gasparri, C., & Perna, S. (2020). Polycystic ovary syndrome management: a review of the possible amazing role of berberine. Arch Gynecol Obstet, 301(1), 53-60.
  6. Sunhe YX, Zhang YH, Fu RJ, Xu DQ, Tang YP. Neuroprotective effect and preparation methods of berberine. Front Pharmacol. 2024 Sep 6;15:1429050. doi:10.3389/fphar.2024.1429050. PMID: 39309003; PMCID: PMC11412855